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چکیده
Growth of Yarrowia lipolvtica W3-180 on a poor C-source in the presence of phenylalanine or tyrosine results in the formation of homogentisic acid. Melanin is formed, if desired, by bringing the medium to pH >10 whereupon the homogentisic acid spontaneously polymerizes. Y. lipolytica YB3-180 was grown in a minimal salts medium contg. 0.5 g glucose/L and tyrosine 5 mM. After 5 days incubation (28.degree., with shaking) 40% of the tyrosine had been converted to homogentisic acid that was recovered by solvent extn. of the acidified medium. Alternatively, the medium was brought to pH 10 with NH40H with the rapid formation of melanin. Wild-type strains produced neither
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تاریخ انتشار 2009